The potential of laminar functional MRI in refining the understanding of epilepsy in humans.

ABSTRACT: Despite decades of development and clinical application, drug-resistant epilepsy occurs in 25%-30% of patients. One limiting factor in the success of antiseizure medications are challenges in mapping the neural effects of epilepsy drugs to seizure mechanisms in humans. Most antiseizure medications were developed in animal models and primarily target nano-scale structures like ion channels and receptors. However, they exert their effects and are typically measured in humans at the macro-scale using techniques like EEG and conventional functional MRI (fMRI). This disconnect between the mechanisms of pharmaceutical interventions and the clinical management of epilepsy leaves a critical gap in our understanding. This is because all seizures, even those of a generalized nature, appear to initia

SUBMITTER: Aitken F 

PROVIDER: S-EPMC12677026 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature