Emotion processing in schizophrenia and its relation to μ-opioid receptor availability.

ABSTRACT:

Background

Emotion processing deficits are core features of schizophrenia, and there is interest in understanding their neurochemical basis. Preclinical evidence implicates opioid neurotransmission in emotional regulation, however the role of the μ-opioid receptor (MOR) in human emotion processing in schizophrenia remains unclear. Here, we examined the association between central MOR availability and emotion processing in patients with schizophrenia.

Methods

Nineteen patients with schizophrenia and 19 age- and sex-matched healthy controls underwent functional MRI (fMRI) while performing two emotion-processing tasks: viewing emotional pictures from the International Affective Picture System (IAPS) and a facial emotion recognition task (happy, sad, neutral faces). All particip

SUBMITTER: Shatalina E 

PROVIDER: S-EPMC12677057 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature