Single-cell and molecular insights into the immunopathogenic mechanisms of oral mucous membrane pemphigoid.

ABSTRACT: Mucous membrane pemphigoid (MMP) is a chronic autoimmune bullous disorder, characterized pathologically by subepidermal blistering inflammation primarily affecting mucosal surfaces. The immunopathogenesis of MMP involves a complex interplay between cytokines, epithelial components, and immune cells, yet the specific cell subsets driving disease progression, especially in oral mucosal lesions, remain poorly defined. To address this gap in knowledge, we performed integrated single-cell transcriptomic and immune repertoire profiling of paired oral mucosal lesions and peripheral blood samples from MMP patients prior to therapeutic intervention. Our analyses uncover a multifaceted pathogenic signature, including aberrant WNT4 signaling, dysfunctional Th17 cell responses, TNF-α-producing macroph

SUBMITTER: Kuang W 

PROVIDER: S-EPMC12677065 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature