Effect of a new plant-based high-energy oral nutritional supplement in adult malnourished patients: an open-label, randomized clinical trial.

ABSTRACT:

Background and aims

The recent global trend toward reducing the consumption of animal-derived products has contributed to a growing demand for plant-based oral nutritional supplement (pbONS) options. PbONS, in addition to achieving good compliance, have an improvement in nutritional status (increased energy and protein intake, body weight, and BMI) on malnourished patients. However, there is no evidence of their impact compared to animal-based ONS (aONS).

Methods

A multicenter, open-label, and non-inferiority trial (NCT06055543) was conducted in 5 tertiary hospitals in Spain. Adult malnourished outpatients requiring high-energy ONS for at least 12 weeks (1.5 kcal/ml;200 ml, 2 bottles/day), having signed informed consent, were recruited and randomly assigned (1:1) to receive

SUBMITTER: Iglesias Hernandez NC 

PROVIDER: S-EPMC12677066 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature