Coordinated upregulation of PABPC1L and SNHG lncRNAs defines a tumor-specific expression module in colorectal cancer: evidence from paired tumor-normal expression profiling.

ABSTRACT: Nonsense-mediated mRNA decay (NMD) has an important role in the pathoetiology of cancer, including colorectal cancer (CRC). Identification of the lncRNAs associated with this function would enhance our understating about the molecular mechanisms of CRC and facilitate design of novel therapies. In the current study, we used a bioinformatics approach to find NMD-associated lncRNAs in CRC. Then, we assessed expression of these genes in 43 paired CRC samples and adjacent non-tumor (ANT) tissues. Three transcripts were significantly overexpressed in tumor tissue: PABPC1L (mean fold-change ≈ 5.20, 95 % CI 2.30-11.85, P = 0.0003), SNHG17 (mean fold-change ≈ 5.46, 95 % CI 2.04-14.50, P = 0.001), and SNHG1 (mean fold-change ≈ 5.82, P = 0.0086). RUSC1-AS1 showed a non-significant trend toward upregu

SUBMITTER: Ghadyani F 

PROVIDER: S-EPMC12677082 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature