Proteomics insights: exploring the inflammatory and metabolic signatures of ethnicity and change in physical activity in non-diabetic hyperglycaemia.

ABSTRACT:

Background

People of South Asian (SA) origin have an elevated risk of cardiometabolic dysfunction and respond differentially to physical activity. Mechanisms underpinning these observations are incompletely understood. We investigated protein signatures of ethnicity, changing physical activity and their interaction.

Methods

A discovery analysis was conducted using data from 794 SA to 49,153 white European (WE) participants in UK Biobank, assessing associations between 726 plasma proteins and physical activity and ethnicity. Findings were validated in a targeted cohort of 58 individuals with non-diabetic hyperglycaemia, taken from a larger randomised controlled trial (PROPELS, n = 1366), stratified by ethnicity and changes in accelerometer assessed physical activity (steps/da

SUBMITTER: Henson J 

PROVIDER: S-EPMC12677085 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature