Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study.

ABSTRACT: The impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer's disease (AD), and its interaction with risk factors like sex and APOE-ε4 carriership, remains unclear. In this study, we examined these associations in a population of older adults without dementia and evaluated the potential of Aβ-PET for risk stratification. We included 1329 participants (56 % female) with an age of 68.2 ± 8.78 years from the prospective multi-center AMYPAD Prognostic and Natural History Study who underwent [¹⁸F]Flutemetamol or [¹⁸F]Florbetaben Aβ-PET and T1-weighted MRI, with longitudinal data for 684 participants (median follow-up = 3.4 years). Linear mixed models assessed the effect of baseline Aβ burden through the Centiloid approach on longitudinal ch

SUBMITTER: Pieperhoff L 

PROVIDER: S-EPMC12677100 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature