Novel 4-quinolone derivative inflicted cytotoxicity via intrinsic apoptotic pathway activation on human metastatic triple-negative breast cancer cells.

ABSTRACT: Quinolones are a class of compounds that have shown promising potential as anticancer agents. However, the current quinolones in clinical trials are currently hampered by their efficacy issues. Therefore, we designed and synthesized novel 4-quinolone-3-carboxamide derivatives 14-67. All the synthesized compounds were initially screened for their cytotoxicity activity using the MTT assay method and evaluated for their anticancer activities against leukemia and breast cancer cells using the Differential Nuclear Staining (DNS) assay. Six screened compounds exhibited low CC₅₀ inhibitory effects against breast cancer cell lines, where compounds 24, 25, 52, and 65 also showed good activity (CC₅₀ = 6.99-11.17 μM) against the leukemia cell line (Jurkat). In vitro assessment s

SUBMITTER: Azzman N 

PROVIDER: S-EPMC12677246 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature