The rsmA mutant from Pseudomonas aeruginosa ID4365 is a non-virulent strain that is suitable for pyocyanin and phenazine-1-carboxylic acid production.

ABSTRACT: Phenazines are compounds of medical and biotechnological interest due to their antimicrobial and antitumoral properties. Pseudomonas aeruginosa, a Gram-negative bacterium, naturally produces phenazines such as pyocyanin and phenazine-1-carboxylic acid (PCA). These phenazines can generate reactive oxygen species, which increase oxidative stress in susceptible cells and ultimately lead to their death. Pyocyanin can inhibit the growth of human bacterial pathogens, while PCA serves as a potent antifungal agent that can prevent and control crop diseases. The environmental strain P. aeruginosa ID4365 overproduces pyocyanin, and its derivative strain IDrsmA, which carries a mutation in the rsmA gene, presents a fivefold increase in pyocyanin production compared to the wild-type strain. This mutan

SUBMITTER: Fabian Del-Olmo MJ 

PROVIDER: S-EPMC12677446 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature