Protective effects of clinical anticholinergic and anticholinesterase agents against Bungarus multicinctus venom and neurotoxin-rich snake venoms.

ABSTRACT: Bungarus multicinctus is one of the most venomous and lethal snake species in mainland China, with envenomation resulting in a mortality rate as high as 23%. Currently, antivenin against B. multicinctus remains the gold standard for treating bites from this species. However, in remote mountainous areas or rural regions of China, access to antivenin may be delayed or unavailable following a bite. The lethal components of B. multicinctus venom include α-, β-, γ- and κ-bungarotoxins, which act on either the presynaptic or postsynaptic membrane, thereby altering acetylcholine levels in the synaptic cleft. This study aims to evaluate pharmaceutical agents that confer prophylactic or protective effects against bungarotoxins and neurotoxin-rich snake venoms. Based on theoretical considerations, w

SUBMITTER: Zhang G 

PROVIDER: S-EPMC12677460 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature