Lysine p-nitroanilide impairs cellular energetics and potentiates statin-induced cytotoxicity in RD rhabdomyosarcoma cells.

ABSTRACT: Statins are clinically effective drugs for treating dyslipidemia and have been proposed as promising antineoplastic and adjuvant agents in cancer therapy for years due to their impact on dysregulated cell growth processes, including cell signaling, energetics, and membrane synthesis. Despite being potent inhibitors of mevalonate synthesis and its downstream products, their limited clinical success highlights the need to further explore their mechanistic effects. Leveraging the observed sensitivity of muscle cells to atorvastatin in clinical settings and utilizing untargeted metabolomic analysis of atorvastatin-treated RD rhabdomyosarcoma cells, we identified reduced levels of aminoadipic acid, an intermediate in lysine catabolism. We investigated whether metabolic sensitization of RD cells

SUBMITTER: Alvarado-Calderon J 

PROVIDER: S-EPMC12677468 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature