Stability of arterial blood gas samples after delayed analysis and mechanical stress.

ABSTRACT:

Purpose

To investigate the effect of prolonged time before analysis and mechanical manipulation on pre-analytical stability of biomarkers and the validity of blood gas analysis results.

Methods

We collected blood samples from 240 ICU patients from May 18, 2022 to March 31, 2023. Samples were analyzed immediately per standard operating procedure, then the syringes were kept at room temperature for 60 min, subjected to standardized mechanical forces (repeated drops) and analyzed again. Thirteen typical blood gas analytes were measured. Bland-Altman plots were prepared to assess differences between initial and delayed analyses. Differences were compared against official accuracy limits specified in German quality assurance guidelines (Rili-BAEK).

Results

For hemoglobin,

SUBMITTER: Gutermuth M 

PROVIDER: S-EPMC12677527 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature