Object location memories recruit distal CA1 and catecholaminergic inputs to proximodistal CA1.

ABSTRACT: The hippocampus is thought to combine "what" and "where" information from the cortex so that objects and events can be represented within the spatial context in which they occur. Surprisingly then, these distinct types of information remain partially segregated in the output region of the hippocampus, area CA1. In this region, objects preferentially activate neurons in the distal segment (adjacent to the subiculum) while spatial locations are precisely represented by neurons in the proximal segment (adjacent to CA2). This difference likely results from distinct anatomical connections; proximal CA1 receives direct input from the medial entorhinal cortex (which encodes spatial context) whereas distal CA1 has reciprocal connections with the lateral entorhinal cortex (which encodes objects and

SUBMITTER: Crestani AP 

PROVIDER: S-EPMC12677530 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature