Comparative effectiveness of adjuvant treatment for hepatocellular carcinoma with high risk of recurrence: A systematic review and network meta-analysis.

ABSTRACT:

Objective

To identify the most effective postoperative intervention regimen for persons with hepatocellular carcinoma (HCC) at high risk of recurrence.

Methods

A network meta-analysis was conducted by collecting eligible studies from Medline, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science databases. Pairwise and network meta-analyses were applied to pooled data on overall survival (OS) and recurrence-free survival (RFS).

Results

35 studies involving 6,372 patients were analyzed. Pairwise meta-analysis showed higher OS (HR = 0.64, 95% CI: 0.56-0.72; P < 0.001; I2 = 70.9%, random effects model) and RFS (HR = 0.62, 95%CI 0.56-0.70; P < 0.001; I2 = 60.2%, random effects model) in the adjuvant intervention group compared to surgery alone. IC

SUBMITTER: Peng Z 

PROVIDER: S-EPMC12677550 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature