Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.

ABSTRACT: The late stage of type 2 diabetes is characterized by secretory dysfunction and increased β-cell apoptosis, but the underlying mechanisms are not fully understood. The expression and function of secretory carrier membrane protein 5 (SCAMP5) in β-cells are unclear. The aim is to explore the role of SCAMP5 in diabetic β-cell failure. SCAMP5 expression is reduced in β-cells under diabetic conditions. Notably, SCAMP5 deficiency diminishes insulin secretion, which is involved in reduced Ca_V1.2 expression. Additionally, decreased SCAMP5 triggers β-cell apoptosis, suggesting the anti-apoptotic role of SCAMP5 in β-cells. Mechanistically, SCAMP5 downregulates the protein expression of voltage-dependent anion channel (VDAC1) and interacts with it, thereby repressing VDAC1-recruited Bax to

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12677586 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature