Regular versus Irregular Exercise Differentially Modulates Hippocampal-Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation.

ABSTRACT: Despite the known benefits of exercise, an in-depth comparison of the effects of regular versus irregular exercise on brain-body interactions and molecular mechanisms remains lacking. This study demonstrates that regular exercise robustly enhances fear memory extinction in mice, whereas irregular exercise has only mild effects. This divergence arises from regular rather than irregular exercise strongly inhibiting axonal mRNA transport and local translation of choline acetyltransferase (ChAT) in septal cholinergic neurons projecting to the hippocampus, thereby reducing hippocampal acetylcholine (ACh) levels and inhibiting α7 nicotinic acetylcholine receptor (α7-nAChR) activation on astrocytes. Critically, this hippocampal ACh-α7-nAChR signaling modulates hepatic ACh via the amygdala-dorsal

SUBMITTER: Ma P 

PROVIDER: S-EPMC12677590 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature