CCL5^hi Macrophages Interact with CD8⁺ T Cells and Potentiate Responsiveness to PD-1 Blockade Plus Chemotherapy in Esophageal Squamous Cell Carcinoma.

ABSTRACT: Immunotherapy has significantly transformed cancer therapy and reinvigorated research in cancer immunology. Several clinical trials have employed neoadjuvant immunochemotherapy (NIC) for advanced esophageal squamous cell carcinoma (ESCC), resulting in significant benefits for many patients. However, response rates remain limited, underscoring the need for more effective screening methods and novel therapeutic strategies. Tumor-associated macrophages (TAMs) have been shown to play a crucial role in tumor progression and impact the clinical outcomes of cancer patients. Nonetheless, it is worth noting that TAMs exhibit phenotypic and functional heterogeneity. In this study, a distinct population of CCL5^hi macrophages is identified that plays a critical role in ESCC when treated wit

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12677597 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature