Identification of a Pair of Linear or Cyclic Naturally Inspired Bifunctional Lipopeptide Antibiotics That Overcome Antimicrobial Resistance.

ABSTRACT: The emergence of multidrug-resistant pathogens presents a major clinical challenge worldwide. The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for the discovery of new classes of antibiotics with distinctive modes of action, which can be unearthed in a scalable manner using a synthetic bioinformatic natural product approach. Here, the discovery of a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and aquicidine C4, with opposite antibacterial spectra, is reported, which are chemically synthesized on the basis of distinct structure prediction of the aquicidine gene cluster from Aquimarina. Aquicidine L mainly targets both anionic lipopolysaccharide and phosphatidylethanolamine in the bacterial membrane and is efficaciou

SUBMITTER: Li L 

PROVIDER: S-EPMC12677607 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature