Tumor-Targeted FABP5/STING Cascade Promote Radiofrequency Ablation Induced Ferroptosis and Intratumoral Immune Rewiring in Hepatocellular Carcinoma.

ABSTRACT: Radiofrequency ablation (RFA) has emerged as a critical therapeutic modality for hepatocellular carcinoma (HCC). Biomimetic magnetic nanoparticles further augment RFA efficacy by enhancing targeting precision and biocompatibility. This study introduces a novel nanocarrier co-delivery system aimed at key molecular targets in HCC to amplify ferroptosis and reprogram intratumoral immunity, thereby improving the therapeutic outcomes of RFA. The proposed nanocarrier integrates cyclic arginine-glycine-aspartic acid (cRGD) and red blood cell membrane (RBCM), encapsulating superparamagnetic iron oxide (SPIO) to specifically target fatty acid-binding protein 5 (FABP5) in tumor cells. Leveraging the superparamagnetic properties of SPIO, these nanoparticles enable real-time monitoring and tracking th

SUBMITTER: Tang B 

PROVIDER: S-EPMC12677646 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature