Estrogen Alleviates Sevoflurane-Induced Neurotoxicity by Inhibiting ERα-Tau Binding.

ABSTRACT: Sevoflurane-induced neurotoxicity is age-dependent, but the role of sex differences is unclear. While testosterone has protective effects, the impact of estrogen remains unknown. This study investigates the effects of sevoflurane on neurotoxicity in adult, middle-aged, and aged male and female mice. Neurotoxic effects are assessed through Tau phosphorylation, cognitive function, transient Ca²⁺ signal amplitude, firing frequency, dendritic spine density, and dendritic axon count in the dorsal hippocampal CA1 (dCA1) region. Estrogen receptor antagonists, inhibitors, and overexpression viral vectors are used to explore estrogen receptor-mediated actions. Protein-protein interactions are analyzed using GRAMM docking and ITC, and competitive ELISA is employed to investigate estrogen'

SUBMITTER: Li F 

PROVIDER: S-EPMC12677654 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature