Disruption of Gut Microbiota-Mediated De Novo NAD⁺ Synthesis Contributes to the Development of Polycystic Ovary Syndrome.

ABSTRACT: Polycystic ovary syndrome (PCOS) is a severe disorder that compromises female ovarian health and elevates the risk of various diseases, including endometrial cancer. The pathogenesis of PCOS remains poorly understood, which has hindered the development of effective interventions. In this study, it is demonstrated that patients with PCOS exhibit significant gut dysbiosis. FMT from PCOS patients (P-FMT) into mice induced PCOS-associated symptoms and histological alterations. Notably, both PCOS patients and P-FMT mice exhibit distinct metabolic profiles in the gut, suggesting a gut microbiota-mediated metabolic reprogramming. Furthermore, impaired tryptophan metabolism, particularly reduced levels of 3-hydroxyanthranilic acid (3-HAA), is observed in both PCOS patients and P-FMT mice. Administ

SUBMITTER: Chen K 

PROVIDER: S-EPMC12677664 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature