Concrete Structure Inspired 3D-Printed Framework Mechanically Reinforced Zwitterionic Hydrogel for Efficient Postoperative Abdominal Adhesion Prevention.

ABSTRACT: Zwitterionic hydrogels, which have been demonstrated to hold great potential in preventing abdominal adhesion, are hindered in clinical translation by their inherent mechanical fragility and structural instability. Inspired by the framework-reinforced composite structure of concrete in building construction, herein, a 3D-printed polymeric framework reinforced zwitterionic lubricating hydrogel (abbreviated as 3DF-LH) is developed, which features high tensile strength internally and optimal lubrication externally. Just like the establishment process of concrete, 3DF-LH is fabricated by infiltrating hydrogel precursor solution, that consisted of GelMA and zwitterionic sulfobetaine methacrylate (SBMA), into the pores of a 3D-printed PCL framework (3DF), followed by UV curing. In vitro studies

SUBMITTER: Song J 

PROVIDER: S-EPMC12677669 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature