PDGFRα<sup>+</sup>DPP4<sup>+</sup> Fibroblasts-Macrophage Crosstalk Induces Orbital Fibrosis in Treatment-Resistant Thyroid Eye Disease via the GAS6-AXL Pathway.
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ABSTRACT: Thyroid eye disease (TED), the leading adult orbital disease, is an autoimmune disorder characterized by fibrosis. Effective anti-fibrotic treatments are scarce, except for orbital decompression surgery involving orbital adipose tissue (OAT) removal, due to high rates of drug resistance following hyperthyroidism treatment and the lack of suitable mouse models. Understanding the mechanisms behind fibrotic remodeling of OAT could aid mouse model development and identify novel therapies. In the present study, stromal vascular fraction cells of OAT from patients with inactive-stage TED, characterized by pronounced fibrosis, are analyzed at single-cell resolution. platelet-derived growth factor receptor (PDGFR)α+dipeptidyl peptidase (DPP)4+ fibroblasts exhibiting progenito
SUBMITTER: Cheng L
PROVIDER: S-EPMC12677676 | biostudies-literature | 2025 Dec
REPOSITORIES: biostudies-literature
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