Single-Cell Immune Profiling Reveals Neutrophils Promote Myasthenia Gravis Exacerbation Through BAFF Secretion.

ABSTRACT: Neutrophils play a critical role in the pathogenesis of autoimmune diseases, including myasthenia gravis (MG), but their specific function in MG exacerbations remains unclear. This study utilizes single-cell RNA sequencing (scRNA-seq) of bone marrow and peripheral blood from MG patients during acute exacerbations, combined with experimental autoimmune myasthenia gravis (EAMG) mouse models and clinical cohort analyses, to investigate the potential involvement of a neutrophil-B-cell activating factor (BAFF) -plasma cell axis. The results reveal that, during MG acute exacerbation, bone-marrow neutrophils exhibit significantly enhanced maturation. Upon migration to the peripheral blood, these neutrophils secrete increased amounts of BAFF, further promoting pathological B-cell differentiation a

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12677686 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature