Nociceptive Nerve-Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b⁺ CD146⁺ Fibroblast Differentiation.

ABSTRACT: Progressive dysmenorrhea and extensive fibrosis within the myometrium are hallmark features of adenomyosis (AM). Approximately 80% of patients with AM experience secondary dysmenorrhea, which occurs more frequently in AM than in other gynecological disorders. Because nociceptive nerves mediate dysmenorrhea, their contribution to AM-associated fibrosis is investigated. These results demonstrate overexpression of calcitonin gene-related peptide (CGRP)+ nociceptive nerves within fibrotic lesions in both AM patients and murine models; nociceptive nerve ablation reduces uterine fibrosis in mice with induced AM. CGRP, secreted by nociceptive nerves, drives receptor activity-modifying protein 1 (RAMP1) high-expressing (RAMP1^hi) CD140b⁺ CD146⁺ fibroblasts in AM les

SUBMITTER: Ye Z 

PROVIDER: S-EPMC12677688 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature