Nanozyme-Engineered Probiotic Microneedle Patch for Chronic Diabetic Wound Therapy.

ABSTRACT: Chronic diabetic wounds are notoriously difficult to heal due to persistent bacterial infection, oxidative stress, and tissue hypoxia. Here, a multifunctional probiotic microneedle (MN) patch embedding platinum nanozyme-engineered Bacillus subtilis (Pt-M@B. sub) within a dissolvable, biocompatible polymer matrix is presented for synergistic diabetic wound therapy. This biohybrid system alleviates reactive oxygen species (ROS), combats bacterial infection, relieves hypoxia, and exerts anti-inflammatory effects. The platinum nanozyme modification protects the probiotics of B. subtilis by scavenging ROS and generating oxygen in situ, thereby enhancing probiotic survival and function under harsh wound conditions. Upon transdermal application, the MN patch (termed Pt-M@B. sub MN patch) enables

SUBMITTER: Wang X 

PROVIDER: S-EPMC12677689 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature