Millikelvin Intracellular Nanothermometry with Nanodiamonds.

ABSTRACT: Nanothermometry within living cells is an important endeavor in physics, as the mechanisms of heat diffusion in such complex and dynamic environments remain poorly understood. In biology, nanothermometry may offer new insights into cellular biology and open new avenues for drug-discovery. Previous studies using various nanothermometers have reported temperature variations of up to several Kelvins during metabolic stimulation, but these findings have remained controversial as they appear to contradict the law of heat diffusion in the presence of heating rates that are consistent with physiological parameters. Here, nanodiamond nanothermometry are reported inside macrophages by measuring the optically detected magnetic resonance spectra of nitrogen-vacancy centers. The spectra are analyzed w

SUBMITTER: Sow M 

PROVIDER: S-EPMC12677697 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature