Antioxidant Carbon Dot of Selenomethionine Alleviates Oxidative Stress in Intervertebral Disc Degeneration.

ABSTRACT: Intervertebral disc degeneration (IVDD) is a progressive degenerative disorder of the spine characterized by oxidative stress and cellular dysfunction. Current clinical treatments for IVDD include surgical procedures, such as discectomy and spinal fusion, as well as pharmacological therapies using analgesics and anti-inflammatory agents. However, these strategies primarily offer symptomatic relief and do not address the underlying causes of IVDD. Targeting oxidative stress has emerged as a promising therapeutic approach, yet its effectiveness remains limited. To overcome this limitation, an antioxidant carbon dot of selenomethionine (Se-Met-CD) is developed for efficient IVDD therapy. Se-Met-CD effectively scavenges excess reactive oxygen species (ROS), alleviates oxidative stress, and res

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12677702 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature