Single-Cell Transcriptomics Reveals ITGA2-Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis.

ABSTRACT: Pediatric papillary thyroid carcinoma (PPTC) has exhibited a progressive increase in incidence in recent years, characterized by heightened biological aggressiveness relative to adult papillary thyroid carcinoma (APTC). Nevertheless, the molecular mechanisms governing PPTC-specific pathobiology remain elusive. Through high-resolution single-cell RNA sequencing analysis of 90234 cellular transcriptomes from 4 PPTC and 9 APTC clinical specimens, a phenotypically distinct cellular subpopulation (ITGA2^hi-PTC cells) mechanistically responsible for PPTC's distinct clinical behavior, is identified. By integrating PPTC-derived organoid models with in vivo functional validation and multiplex immunohistochemistry, it is demonstrated that ITGA2 orchestrates dual oncogenic pathways: 1) augm

SUBMITTER: Zhan ZJ 

PROVIDER: S-EPMC12677704 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature