Expression profiles of itch markers during scabies infection in a porcine scabies model.

ABSTRACT:

Background

Scabies is a debilitating parasitic skin disease caused by the obligate parasitic mite Sarcoptes scabiei, which inhabits the upper layers of the epidermis. In over 90% of affected individuals intense itching is the primary clinical symptom. This is accompanied by other delayed-type hypersensitivity responses. Persistent scratching due to the itch compromises skin integrity, facilitating the entry of pathogenic bacteria. Combined with immune-modulatory factors secreted by the mites, this creates a permissive environment for bacterial colonisation often leading to secondary complications. Effective treatment of scabies-associated itch could significantly reduce these complications and improve patients' quality of life. However, current antipruritic therapies are inadequate

SUBMITTER: Fernando DD 

PROVIDER: S-EPMC12677767 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature