ORF45-induced Filamin A phosphorylation promotes cell motility and cell-contact dependent viral infection of Kaposi's sarcoma-associated herpesvirus.

ABSTRACT: Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman disease. Studies have shown that cell-to-cell viral infection plays a key role in KSHV transmission in vivo, and differentiated B cells and endothelial cells might represent two distinct kinds of natural donors or recipients that radically support the lytic cycle of KSHV. Consistent with the observation that endothelial cells exhibit better acceptance and transmissibility than B lymphocytes in cell-cell contact-mediated KSHV transmission, the sequential cell detachment, migration and cell-cell contact is the determinant for this kind of viral transmission. To investigate the processes and regulation of cell-cell contact-mediated viral infection d

SUBMITTER: Li X 

PROVIDER: S-EPMC12677772 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature