Quality of Life and Metabolomics Analysis in Response to Meal Kit Intervention During Perioperative Chemotherapy in Patients with Early-Stage Breast Cancer: Protocol for a Single-Center Phase Ⅱ Randomized Crossover Trial.

ABSTRACT:

Background

Patients with breast cancer undergoing chemotherapy experience significant adverse effects, including fatigue, nausea, and taste alterations, leading to malnutrition in 40% of patients. Traditional nutritional counseling has shown limited effectiveness in addressing these challenges during treatment.

Objective

This study aimed to evaluate the impact of a structured meal kit intervention on quality of life and metabolomic profiles in patients with breast cancer during perioperative anthracycline and taxane-based chemotherapy.

Methods

This single-center phase 2 randomized crossover trial will enroll 20 patients with breast cancer scheduled for perioperative chemotherapy at Jikei University Hospital between October 2024 and October 2025. Patients will be rando

SUBMITTER: Fushimi A 

PROVIDER: S-EPMC12677867 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature