Prenatal exposure to metal(loid)s mixture and childhood lung function: Exploring sex-specific associations.

ABSTRACT:

Background

The link between prenatal exposure to metal(loid)s and childhood lung function, including sex-specific effects, has not been completely elucidated. We aimed to examine sex-specific individual and joint effects of prenatal metal(loid)s exposure on children's lung function.

Methods

Analyses included 438 mother-child dyads from the Programming Research in Obesity, Growth, Environment, and Social Stressors birth cohort in Mexico City. Metal(loid)s levels (As, Cd, Co, Cu, Mn, Ni, Pb, Se, and Zn) were measured in maternal blood collected during the second and third trimesters. Lung function in children was assessed once at ages 8-14 years. Multiple linear regression was performed to evaluate individual associations. Mixture effects were assessed through repeated holdout

SUBMITTER: Garza MJ 

PROVIDER: S-EPMC12677884 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature