Antiarrhythmic drugs for cardiac arrest with a shockable rhythm and their effect on outcomes: a systematic review with meta-analysis.

ABSTRACT:

Aims

Antiarrhythmic drugs are used during cardiopulmonary resuscitation (CPR) to improve the chances of return of spontaneous circulation (ROSC) in shockable rhythms. To date, their impact on clinical outcomes remains uncertain. This review aimed to provide an evaluation of respective up-to-date evidence.

Methods and results

We searched Embase, MEDLINE®, and Cochrane Central Register of Controlled Trials. Data on study design, population characteristics, antiarrhythmic drugs used, and predefined outcomes were extracted. A meta-analysis was conducted in groups with at least three studies reporting the same outcome. Additionally, we performed subgroup analysis according to the study design. Initially, 5080 studies were identified, and 29 were included, with, in total, 60 205 p

SUBMITTER: Schnaubelt S 

PROVIDER: S-EPMC12677910 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature