POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population.

ABSTRACT: Loss-of-function mutations in the transcription factor POU3F2 have been identified in individuals with neurodevelopmental disorders. To elucidate the mechanistic role of POU3F2 in human neurodevelopment, we induced POU3F2 disruption in human neural progenitor cells (NPCs). Mutation of POU3F2 in NPCs causes reduced baseline canonical Wnt signalling and decreased proliferation, resulting in premature specification of radial glia. Additionally, POU3F2 levels across genetically diverse NPCs significantly associate positively with baseline canonical Wnt signalling and negatively with markers of radial glia specification. Through a series of unbiased analyses, we show that SRY-box transcription factor 13 (SOX13) and activity dependent neuroprotector homeobox (ADNP) are transcriptional targets of

SUBMITTER: Benoit CR 

PROVIDER: S-EPMC12677912 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature