Safety and Efficacy of Respiratory Syncytial Virus Vaccination in Older Adults: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Although the respiratory syncytial virus (RSV) membrane protein F has become one of the major target proteins for RSV vaccine development, previous studies have identified safety issues with RSV vaccines in older adults. The causes of these issues remain unclear.

Objective

We aimed to evaluate the safety and efficacy of a novel RSV preF vaccine in preventing lower respiratory tract infections (LRTIs) and RSV-associated acute respiratory illnesses (RSV-ARIs) in older adults.

Methods

We conducted a systematic review of randomized controlled trials from 5 databases-PubMed, Embase, the Cochrane Library, Web of Science, and the Cochrane Central Register of Randomized Controlled Trials-published up to July 31, 2024. For categorical variables, we used the risk rat

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC12677982 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature