Post-methamphetamine working memory decline predicts relapse vulnerability in rats and is rescued by mGlu3 receptor activation.

ABSTRACT:

Rationale

Widespread methamphetamine (meth) misuse remains a worldwide public health issue that lacks effective clinical treatment. Besides the high relapse and overdose rates, chronic meth use produces a spectrum of cognitive deficits that further complicate treatment and recovery. Activation of metabotropic glutamate receptor 3 (mGlu3) attenuates drug-seeking behavior and/or improves cognition in several animal models, though its ability to improve meth-associated behavioral deficits has not been explored.

Objectives

Here, we evaluated working memory and meth-seeking following abstinence and the effects of mGlu3 activation on such behaviors.

Methods

Adult male and female Sprague-Dawley rats were first trained and tested on the operant delayed match-to-sample (DMS) w

SUBMITTER: Modrak CG 

PROVIDER: S-EPMC12677998 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature