Positionally distinct interferon-stimulated dermal immune-acting fibroblasts promote neutrophil recruitment in Sweet syndrome.

ABSTRACT:

Background

Sweet syndrome is an inflammatory skin disease characterized by robust neutrophil infiltration into the dermis. The pathogenesis of Sweet syndrome and its distinguishing features compared to other neutrophilic dermatoses, such as pyoderma gangrenosum, remain poorly understood.

Objective

Our aim was to define the cellular and molecular landscape of the skin of patients with Sweet syndrome.

Methods

Single-nucleus and bulk transcriptomics were performed on archival clinical skin samples from patients with Sweet syndrome, patients with pyoderma gangrenosum, and healthy controls. For mechanistic validation, functional experiments were performed with primary human cells. Spatial transcriptomics with single-molecule resolution was used to map cell types to tissue

SUBMITTER: Cavagnero KJ 

PROVIDER: S-EPMC12678022 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature