School Performance After Maintenance Tocolysis With Nifedipine for Threatened Preterm Birth: 12-Year Follow-Up of the APOSTEL 2 Trial.

ABSTRACT:

Objective

To evaluate school performance at 12 years of age in children prenatally exposed to maintenance tocolysis with nifedipine versus placebo.

Design

12-year follow-up of the multicentre APOSTEL 2 trial, in which participants with threatened preterm birth between 26⁺⁰ and 32⁺² weeks of gestation, who remained pregnant after initial 48-h tocolysis, were randomised to nifedipine maintenance tocolysis or placebo for up to 12 days.

Setting

The APOSTEL 2 trial was conducted in 11 Dutch hospitals from 2008 to 2010. School outcomes were assessed at age 12.

Participants

Children from singleton and multiple pregnancies born to APOSTEL 2 participants.

Methods

School performance data were received through linkage with a national registry

SUBMITTER: van der Windt LI 

PROVIDER: S-EPMC12678038 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature