TREM2 Deficiency Regulates Macrophage Apoptosis and Repair in Radiation-Induced Skin Injury.

ABSTRACT: Radiation-induced skin injury (RISI) is a common and debilitating complication of radiotherapy, characterized by persistent inflammation and delayed wound healing. Macrophages play a central role in this process; however, the molecular mechanisms governing their dysfunction under radiation stress remain poorly understood. To elucidate the role of triggering receptor expressed on myeloid cells 2 (TREM2) in macrophage regulation after irradiation, we combined single-cell RNA sequencing, in vivo mouse models, and in vitro macrophage assays. Conditional knockout mice (LysM ^Cre Trem2 ^flox/flox) were used to selectively delete Trem2 in macrophages. Radiation induced a distinct TREM2⁺ macrophage subset; however, despite elevated Trem2 m

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12678054 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature