Anti-Inflammatory Effect of 21<i>α</i>-Methylmelianol In Vitro and In Vivo via NF-<i>κ</i>B/STAT Signaling Pathway Modulation.

ABSTRACT: Melia azedarach L., also known as the chinaberry tree, has long been used in traditional medicine to treat inflammatory conditions. In this study, we preliminarily investigated the anti-inflammatory effect of 21α-methylmelianol (MMN), a tirucallane-type triterpenoid isolated from M. azedarach, in lipopolysaccharide (LPS)-mediated RAW264.7 macrophages in vitro and in a dextran sodium sulfate (DSS)-stimulated ulcerative murine colitis model in vivo. MMN reduced LPS-stimulated nitric oxide production without inducing cytotoxicity. It significantly attenuated LPS-induced protein expression of reactive oxygen species and effectively suppressed the production of pro-inflammatory factors, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and IL-1β</

SUBMITTER: Cao F 

PROVIDER: S-EPMC12678060 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature