Association of baseline osteocalcin and femoral neck bone mineral density in healthy women with future risk of fractures, cardiovascular disease, diabetes and death.

ABSTRACT:

Purpose

This study aimed to explore relationships between baseline bone metabolism markers and long-term outcomes, collectively referred to as fractures, cardiovascular diseases, diabetes and all-cause death (FCDD), in healthy women at baseline and identify predictive markers for outcome.

Methods

This study included 356 healthy women and assessed baseline bone turnover markers-osteocalcin, C-telopeptide of type I collagen-as well as bone mineral densities (BMDs) at lumbar spine (L1-4), femoral neck (FN) and total hip (TH). A 16-year retrospective follow-up via telephone questionnaire tracked FCDD occurrence. Statistical tests, including univariate analysis, forward stepwise regression and logistic regression analysis, were used to determine correlations between baseline mark

SUBMITTER: Pan ZC 

PROVIDER: S-EPMC12678083 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature