Medicine-food homology bioactives in Parkinson's disease: multi-target oxidative-stress modulation and translation to dietary supplements.

ABSTRACT:

Background

No proven disease-modifying therapy exists for Parkinson's disease (PD), and prior single-target antioxidants have shown limited, unsustained benefits, highlighting the need for safe multi-target strategies.

Objective

To synthesize how medicine-food homology (MFH) compounds from Traditional Chinese Medicine (TCM)-polysaccharides, saponins/triterpenoids, polyphenols, carotenoids, and aromatic phenylpropanoids-modulate oxidative stress and PD-related neurodegeneration, and to outline formulation routes toward dietary-supplement development.

Methods

We searched PubMed, Web of Science Core Collection, Embase (Ovid), and the Cochrane Library from inception through August 1, 2025 with prespecified concept blocks ("Parkinson's disease," "oxidative stress," Nrf2/AR

SUBMITTER: Wang M 

PROVIDER: S-EPMC12678100 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature