Nomogram for predicting risk of arm lymphedema following axillary lymph node dissection in breast cancer patients.

ABSTRACT:

Purpose

Breast cancer-related arm lymphedema (BCRaL) is a prevalent and severe complication post-breast cancer treatment, especially following axillary lymph node dissection (ALND). This study aimed to develop a nomogram for BCRaL risk prediction by identifying and integrating key risk factors, including chemotherapy type (neoadjuvant vs. adjuvant), to enhance individualized patient monitoring and prevention strategies.

Patients and methods

We conducted a retrospective analysis of clinical data from 535 breast cancer patients who received ALND and chemotherapy. Patients were divided into a training cohort (70%) and a validation cohort (30%). Univariate and multivariate Cox regression analyses identified independent risk factors for BCRaL, which were subsequently used to cons

SUBMITTER: Jia M 

PROVIDER: S-EPMC12678132 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature