LncRNA <i>ELDR</i> promotes bladder cancer malignant progression by regulating the miR-1343-3p/<i>TRIM44</i> axis.

ABSTRACT:

Introduction

Bladder cancer (BCa) is one of the most prevalent genitourinary malignancies with high recurrence worldwide. A lack of reliable prognostic biomarkers and effective therapeutic targets hinders its treatment. Emerging evidence indicates that long noncoding RNAs (lncRNAs) are involved in human cancers, including BCa. While lncRNAs hold enormous promise, their specific roles and mechanisms in BCa remain largely unexplored. Here, we identify the lncRNA ELDR as a pivotal oncogenic driver in BCa.

Methods

RT-qPCR was used to analyze the expression patterns of ELDR, miR-1343-3p and TRIM44. CCK-8, colony formation, EdU, and Transwell assays were used to detect the effect of ELDR on cell proliferation, migration, and invasion. The association between ELDR, miR-1343-3p and

SUBMITTER: Hu X 

PROVIDER: S-EPMC12678138 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature