Associations between composite systemic inflammation indicators(CAR, CLR, SII, AISI, SIRI, and CALLY) and metabolic dysfunction-associated fatty liver disease (MAFLD): evidence from a two-stage study in China.

ABSTRACT:

Background

The redefinition from nonalcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated fatty liver disease (MAFLD) highlights metabolic dysfunction's central role. While systemic inflammation drives MAFLD, large-scale evidence linking novel composite immune-inflammatory markers to MAFLD remains limited. This study evaluates six such markers and their association with MAFLD risk in a two-stage study in China.

Methods

This two-stage study included a case-control analysis (7,894 MAFLD cases and matched controls) and a prospective cohort study (8,627 participants, median follow-up 2.37 years). Six composite immune inflammation-related markers (CAR, CLR, SII, AISI, SIRI, and CALLY) were derived from routine blood tests. Multivariable logistic and Cox regres

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12678147 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature