Integrated analysis for drug repositioning in migraine using genetic evidence and claims database.

ABSTRACT:

Introduction

Migraine is a prevalent neurological disorder with a substantial socioeconomic burden, underscoring the need for continued identification of therapeutic targets. Given the significant role of genetic factors in migraine pathogenesis, a genetic-based approach is considered effective for identifying potential therapeutic targets. This study aimed to identify candidate treatments for migraine by integrating genome-wide association study (GWAS) data, perturbagen profiles, and a large-scale claims database.

Methods

We used published GWAS data to impute disease-specific gene expression profiles using a transcriptome-wide association study approach. The imputed gene signatures were cross-referenced with perturbagen signatures from the LINCS Connectivity Map to identify

SUBMITTER: Inokuchi S 

PROVIDER: S-EPMC12678156 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature