Resting state electroencephalography alpha activity predicts cognitive scores in rapid eye movement sleep behavior disorder.

ABSTRACT: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by the loss of atonia during REM sleep, causing dream-enacting behavior. Although iRBD occurs without any clear signs of neurodegenerative disorders, most patients with iRBD eventually develop Parkinson's disease or dementia with Lewy bodies, typically accompanied by cognitive decline. Hence, identifying a biomarker that reflects a neurophysiological state of iRBD has therapeutic potential. Here, we show that spatially clustered alpha (8-12 Hz) oscillatory activities in the scalp can predict cognitive performance in patients with iRBD. A cohort of 62 Korean patients with iRBD underwent resting-state electroencephalography (rsEEG) recordings and participated in the Montreal Cognitive Assessment tests, a comm

SUBMITTER: Angerbauer R 

PROVIDER: S-EPMC12678165 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature