A comparison of voxel sampling approaches for intensity-modulated radiation therapy.

ABSTRACT:

Background

Intensity-modulated radiation therapy (IMRT) treatment planning technology has made personalized cancer care a reality for millions of patients in recent decades. The complexity of these tools, however, often leads to intractability and suboptimal mitigation strategies in otherwise well-optimized plans. An example of such a strategy is reducing data granularity through voxel sampling.

Purpose

While the practice of sampling is nearly universal in treatment planning, methods vary widely across studies and clinical practices, and few studies directly compare these approaches. The goal of this study is to examine the relative quality loss of some of the more common voxel sampling methods proposed in the literature.

Methods

Five core sampling approaches identifi

SUBMITTER: Ripsman D 

PROVIDER: S-EPMC12678227 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature