Pathogen spectrum, clinical traits and exploration of mortality outcome-improving medication regimens in coinfection patients with severe fever with thrombocytopenia syndrome: a multicenter cohort study.

ABSTRACT:

Purpose

Using a multicenter clinical data, this study aimed to systematically analyze the clinical characteristics, pathogen spectrum, and independent risk/protective factors for coinfection in SFTS patients; additionally, it sought to explore optimal therapeutic regimens to reduce the case fatality rate of SFTS patients with coinfection.

Methods

Clinical data of 1,675 patients with SFTS who were hospitalized for the first time, collected from 6 institutions between May 2011 and November 2024, were included and analyzed.

Results

The coinfection group had a significantly higher case fatality rate (24.3% vs. 6.7%, P < 0.001), with the mixed bacterial-fungal infection subgroup showing the highest mortality risk (Log-rank test, P < 0.001). Albumin served as

SUBMITTER: Fan Z 

PROVIDER: S-EPMC12678257 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature